What is Regenerative Plasma Concentrate (RPC)?
Regenerative Plasma Concentrate (RPC) is an advanced form of bioactive plasma therapy developed by Dr. John Hughes to enhance tissue repair, reduce inflammation, and accelerate healing. This ozonated regenerative plasma treatment combines concentrated platelet growth factors (from both platelet-rich and platelet-poor plasma), autologous stem cells, essential nutrients, and therapeutic peptides. Harvested from the patient’s own blood through a simple draw, RPC is prepared and infused to stimulate cellular regeneration, support recovery from injuries, and optimize overall brain function.
What is Regenerative Plasma Concentrate (RPC) used to Treat?
- Traumatic Brain Injury (TBI)
- Concussion
- Post-Traumatic Stress Disorder (PTSD)
- Neurological Decline
- Alzheimer’s Disease
- Memory Issues
- As well as orthopoedic conditions
“In June 2017, I went in for my second intranasal stem cell procedure and by August I felt well enough that I started saying yes again to facilitating events and speaking gigs. I also experienced relief from anxiety. Within 8-12 weeks post procedure I experienced a noticeable jump in my healing. TBI Therapy has turned me into a TBI THRIVER, not just a survivor. I’m happy. I enjoy life again, can travel and am doing work in the world that’s more aligned with myself than ever.”
Intranasal RPC Procedure
At our medical clinics in Aspen and Basalt, Colorado, we offer Regenerative Plasma Concentrate (RPC)—a form of advanced bioactive plasma therapy designed to support neurological and cellular regeneration. The process begins with a simple blood draw, from which the patient’s own plasma is extracted and refined.
During preparation, patients receive a customized nutrient IV infusion to enhance mitochondrial health, optimize recovery, and improve overall treatment efficacy.
Once activated, the RPC is administered using Dr. John Hughes’ patented intranasal catheter, which delivers the plasma cocktail to the upper nasal cavity for direct access to the brain’s regenerative pathways. Patients recline comfortably with the head positioned for optimal absorption while the RPC integrates into targeted neural tissues. The full procedure lasts approximately two hours, including a 15-minute infusion period.
Following treatment, patients typically resume normal activities the same day. Many report a sense of calm, clarity, or mild euphoria within hours, along with improved cognitive function over time. The most noticeable regenerative results generally emerge within one to three months.
For enhanced outcomes, RPC or stem cell infusions can be paired with Hyperbaric Oxygen Therapy (HBOT) sessions before and after treatment to further stimulate oxygen delivery, tissue repair, and brain recovery.
Individual responses vary; no specific results are guaranteed.
What does Regenerative Plasma Concentrate (RPC) Cost?
The RPC intranasal and IV infusion is offered at $5,500.
For patients seeking a more comprehensive approach, TBI Therapy offers multi-day packages (2-, 3-, and 10-day options) that may include hyperbaric oxygen therapy (HBOT), intranasal insulin, blood draws, cognitive and brainwave assessments, and additional supportive therapies tailored to optimize neurological recovery.
Please note that these services are not billed to insurance. However, we can provide a superbill upon request to assist with potential out-of-network reimbursement.