Hyperbaric Oxygen Therapy

Boussi-Gross, R., Golan, H., Fishlev, G., Bechor, Y., Volkov, O., et al. (2013) Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury – Randomized Prospective Trial. PLoS ONE 8(11): e79995. doi: 10.1371/journal.pone.0079995.

Cifu, D. X., Hart, B. B., West, S. L., Walker, W., & Carne, W. (2014). The effect of hyperbaric oxygen on persistent postconcussion symptoms. The Journal of head trauma rehabilitation, 29(1), 11-20.

Deng, Z., Chen, W., Jin, J., & Zhao, J. (2018). The Neuroprotection Effect of Oxygen Therapy: A Systematic Review and Meta‑analysis. Nigerian journal of clinical practice, 21(4).

Douglas Shytle R, Eve DJ, Kim SH, Spiegel A, Sanberg PR, Borlongan CV. Retrospective Case Series of Traumatic Brain Injury and Post-Traumatic Stress Disorder Treated with Hyperbaric Oxygen Therapy. Cell Transplant. 2019 May 28:963689719853232. [Epub ahead of print].

Efrati, S., Fishlev, G., Bechor, Y., Volkov, O., Bergan, J., Kliakhandler, K., … & Golan, H. (2013). Hyperbaric oxygen induces late neuroplasticity in post stroke patients-randomized, prospective trial. PloS one, 8(1), e53716.

Efrati, S., & Ben-Jacob, E. (2014). Reflections on the neurotherapeutic effects of hyperbaric oxygen. Expert review of Neurotherapeutics,14(3), 233-236.

Eve, D. J., Steele, M. R., Sanberg, P. R., & Borlongan, C. V. (2016). Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatric disease and treatment, 12, 2689.

Fattori, B., Nacci, A., Casani, A., Donati, C., & De Iaco, G. (2001). [Oxygen therapy in the long term treatment of Meniere’s disease]. Acta otorhinolaryngologica Italica: organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 21(1), 1-9.

Figueroa, X. A., & Wright, J. K. (2016). Hyperbaric oxygen B-level evidence in mild traumatic brain injury clinical trials. Neurology, 87(13), 1400-1406.

Gunther, N. & Queen, E. (2013). What Physical and Cognitive Rest Really Mean After a Concussion. Brainline. Retrieved from http://www.brainline.org/content/multimedia.php?id=9022

Hadanny, A., Abbott, S., Suzin, G., Bechor, Y., & Efrati, S. (2018). Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ open, 8(9), e023387.

Hadanny, A., & Efrati, S. (2016). Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: current status and future directions. Expert review of neurotherapeutics, 16(8), 875-887.

Hadanny, A., Golan, H., Fishlev, G., Bechor, Y., Volkov, O., Suzin, G., … & Efrati, S. (2015). Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage.Restorative neurology and neuroscience, 33(4), 471-486.

Harch, P. G. (2022). Systematic review and dosage analysis: hyperbaric oxygen therapy efficacy in mild traumatic brain injury persistent postconcussion syndrome. Frontiers in neurology, 160.

Harch, P. G., Andrews, S. R., Rowe, C. J., Lischka, J. R., Townsend, M. H., Yu, Q., & Mercante, D. E. (2020). Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial. Medical gas research, 10(1), 8.

Harch PG, Fogarty EF. Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report. Med Gas Res. 2018;8(4):181-184.

Harch, P. G., Andrews, S. R., Fogarty, E. F., Lucarini, J., & Van Meter, K. W. (2017). Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder. Medical Gas Research, 7(3), 156–174. http://doi.org/10.4103/2045-9912.215745

Harch, P. G.. (2017) HBOT 2017, 11^th International Symposium. TBI: No Need to Die! A review of HBOT in Acute Severe Traumatic Brain Injury with an Extension to Acute Concussion, and an Update on Chronic Mild TBI.

Harch, P. G., Andrews, S. R., Fogarty, E. F., Amen, D., Pezzullo, J. C., Lucarini, J., … & Van Meter, K. W. (2012). A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder. Journal of neurotrauma, 29(1), 168-185.

Harch, P. G., Fogarty, P. G., Staab, P. K., & Van Meter, K. (2009). Low pressure hyperbaric oxygen therapy and SPECT brain imaging in the treatment of blast-induced chronic traumatic brain injury (post-concussion syndrome) and post traumatic stress disorder: a case report. Cases Journal, 2(1), 1-5.

Hardy, P., Johnston, K. M., De Beaumont, L., Montgomery, D. L., Lecomte, J. M., Soucy, J. P., … & Lassonde, M. (2007). Pilot case study of the therapeutic potential of hyperbaric oxygen therapy on chronic brain injury.Journal of the neurological sciences, 253(1), 94-105.

Hu, Q., Manaenko, A., Xu, T., Guo, Z., Tang, J., & Zhang, J. H. (2016). Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside. Medical Gas Research, 6(2), 102–110. http://doi.org/10.4103/2045-9912.184720

Huang, L., & Obenaus, A. (2011). Hyperbaric oxygen therapy for traumatic brain injury. Medical Gas Research, 1, 21. http://doi.org/10.1186/2045-9912-1-21.

Hughes, J. (2018). Case Report for a mTBI Patient Treated with Intermittent Home HBOT, Intranasal and IV PRP Cocktail, Intranasal Pluripotent Stem Cells from Peripheral Blood, Intranasal Insulin, Cranial Osteopathy, and a Ketogenic Diet.

Hughes, J. (2016). Case Report for TBI (Traumatic Brain Injury) Patient Treated with A Protocol of HBOT (Hyperbaric Oxygen Therapy), Autologous Human Plasma, Cranial Therapy, EEG Biofeedback, IV Nutrition, and Adult Stem Cells.

Hyperbaric Oxygen for Parkinson’s. Retrieved from https://www.txhbo.com/hyperbaric-oxygen-therapy-for-parkinsons/

Lavrnja, I., Parabucki, A., Brkic, P., Jovanovic, T., Dacic, S., Savic, D., … & Pekovic, S. (2015). Repetitive hyperbaric oxygenation attenuates reactive astrogliosis and suppresses expression of inflammatory mediators in the rat model of brain injury. Mediators of inflammation, 2015.

Lin, K. C., Niu, K. C., Tsai, K. J., Kuo, J. R., Wang, L. C., Chio, C. C., & Chang, C. P. (2012). Attenuating inflammation but stimulating both angiogenesis and neurogenesis using hyperbaric oxygen in rats with traumatic brain injury. Journal of Trauma and Acute Care Surgery, 72(3), 650-659.

Lin, J. W., Tsai, J. T., Lee, L. M., Lin, C. M., Hung, C. C., Hung, K. S., … & Chiu, W. T. (2008). Effect of hyperbaric oxygen on patients with traumatic brain injury. In Reconstructive Neurosurgery (pp. 145-149). Springer, Vienna.

Liu, Z., Wang, X., Wu, Z., Yin, G., Chu, H., & Zhao, P. (2023). HBOT has a better cognitive outcome than NBH for patients with mild traumatic brain injury: A randomized controlled clinical trial. Medicine, 102(37).

LDN 2019 Conf Cooper Talk retrieved June 14, 2019.

Mac Donald, C. L., Barber, J., Jordan, M., Johnson, A. M., Dikmen, S., Fann, J. R., & Temkin, N. (2017). Early clinical predictors of 5-year outcome after concussive blast traumatic brain injury. JAMA neurology, 74(7), 821-829.

Miskin, B. M., Fox, L. A., Abou-Al-Shaar, H., Bin-Alamer, O., Goertz, A., Lipin, C. T., … & Cox, N. (2023). Hyperbaric Oxygen Therapy for the Management of Mild and Moderate Traumatic Brain Injury: A Single-Center Experience. World Neurosurgery.

Mozayeni BR, Duncan W, Zant E, Love TL, Beckman RL, Stoller KP. The National Brain Injury, Rescue and Rehabilitation Study – a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms. Med Gas Res. 2019;9(1):1-12.

Nishikawa, M., Kumakura, Y., Young, S. N., Fiset, P., Vogelzangs, N., Leyton, M., … & Diksic, M. (2005). Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using α-[11C] methyl-L-tryptophan and positron emission tomography. Neurochemistry international, 47(8), 556-564.

Nourmohammadi, A., Doaee, M., Fazel, A. M., & Mousavi, S. A. (2017). Hyperbaric Oxygen Therapy and Quality of Life: A Systematic Review. Annals of Military and Health Sciences Research, 15(1).

Parkinson’s and HBOT. Retrieved from https://sarasgarden.org/wp-content/uploads/2013/12/Parkinson%E2%80%99s-Disease-and-HBOT.pdf

Peterson, K., Bourne, D., Anderson, J., Boundy, E., & Helfand, M. (2018). Evidence brief: hyperbaric oxygen therapy (HBOT) for traumatic brain injury and/or post-traumatic stress disorder. VA Evidence Synthesis Program Evidence Briefs [Internet].

Rockswold, S. B., Rockswold, G. L., Zaun, D. A., Liu, J. (2013). A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury. Journal of Neurosurgery. 8(6):1317-28. doi: 10.3171/2013.2.JNS121468.

Rosario, E. R., Kaplan, S. E., Khonsari, S., Vazquez, G., Solanki, N., Lane, M., … & Rosenberg, S. S. (2018). The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke. Neurology Research International, 2018.

Sahni, T., Jain, M., Prasad, R., Sogani, S. K., & Singh, V. P. (2012). Use of hyperbaric oxygen in traumatic brain injury: Retrospective analysis of data of 20 patients treated at a tertiary care centre. British journal of neurosurgery,26(2), 202-207.

Shi, X. Y., Tang, Z. Q., Sun, D., & He, X. J. (2006). Evaluation of hyperbaric oxygen treatment of neuropsychiatric disorders following traumatic brain injury. CHINESE MEDICAL JOURNAL-BEIJING-ENGLISH EDITION-,119(23), 1978.

Silliphant, D. (2017) How hyperbaric oxygen therapy works so well. Retrieved October 21, 2019 from https://www.hyperbariccentral.com/hyperbaric-will-accomplish-health-needs/

Stoller, K. P. (2015). All the right moves: the need for the timely use of hyperbaric oxygen therapy for treating TBI/CTE/PTSD. Medical gas research, 5(1), 1-7.

Stoller, K. P. (2011). Hyperbaric oxygen therapy (1.5 ATA) in treating sports related TBI/CTE: two case reports. Medical gas research, 1(1), 1-6.

Tal, S., Hadanny, A., Sasson, E., Suzin, G., & Efrati, S. (2017). Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Frontiers in Human Neuroscience, 11, 508.

Tal, S., Hadanny, A., Berkovitz, N., Sasson, E., Ben-Jacob, E., & Efrati, S. (2015). Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury. Restorative Neurology and Neuroscience. 33(6):943-51. doi: 10.3233/RNN-150585.

Thom, S. R., Bhopale, V. M., Velazquez, O. C., Goldstein, L. J., Thom, L. H., & Buerk, D. G. (2006). Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology-Heart and Circulatory Physiology, 290(4), H1378-H1386.

Wang, F., Wang, Y., Sun, T., & Yu, H. L. (2016). Hyperbaric oxygen therapy for the treatment of traumatic brain injury: a meta-analysis. Neurological Sciences, 37(5), 693-701.

Weil, L., Kol, C. P., Sul, K., & Chiu, W. T. (2008). Effect of hyperbaric oxygen on patients with traumatic brain injury. Acta Neurochirurgica Supplements Editor: H.-J. Steiger, 101, 145-149.

Wolf, G. E., & 59th Medical Wing. (2020). Primary Blast Injury-The Often Overlooked Hyperbaric Oxygen Indication.

Wolf, E. G. (2017). Traumatic Brain Injury and Hyperbaric Oxygen Therapy: Dawn of a New Day. Presented at APWCA 16^th Annual National Clinical Conference, 7-9 Sep 17.

Wolf, E. G., Baugh, L. M., Kabban, C. M., Richards, M. F., & Prye, J. (2015). Cognitive function in a traumatic brain injury hyperbaric oxygen randomized trial. SCHOOL OF AEROSPACE MEDICINE WRIGHT PATTERSON AFB OH AEROSPACE MEDICINE DEPT.

Wolf, G., Cifu, D., Baugh, L., Carne, W., & Profenna, L. (2012). The effect of hyperbaric oxygen on symptoms after mild traumatic brain injury. Journal of neurotrauma, 29(17), 2606-2612.

Wright, J. K., Zant, E., Groom, K., Schlegel, R. E., & Gilliland, K. (2009). Case report: treatment of mild traumatic brain injury with hyperbaric oxygen.

Xu, J. J., Yang, S. T., Sha, Y., Ge, Y. Y., & Wang, J. M. (2018). Hyperbaric oxygen treatment for Parkinson’s disease with severe depression and anxiety: A case report. Medicine, 97(9), e0029. doi:10.1097/MD.0000000000010029

Find many more resources here: PGH Master Bibliography HBOT Research and Science 6-1-2023

Intranasal Platelet Rich Plasma and Insulin

Anitua, E., Tejero, R., Alkhraisat, M. H., & Orive, G. (2013). Platelet-rich plasma to improve the bio-functionality of biomaterials. BioDrugs, 27(2), 97-111. doi: 10.1007/s40259-012-0004-3

Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H., Born, J., & Kern, W. (2004). Intranasal insulin improves memory in humans. Psychoneuroendocrinology, 29: 1326-133. doi:10.1016/j.psyneuen.2004.04.003.

Benedict, C., Frey, W., Schiöth, H., Schultes, B., Born, J., & Hallschmid, M. (2011). Intranasal insulin as a therapeutic option in the treatment of cognitive impairments. Experimental Gerontolgy, 46: 112-115. doi:10.1016/j.exger.2010.08.026.

Benedict, C., Hallschmid, M., Schmitz, K., Schultes, B., Ratter, F., Fehm, H., Born, J., & Kern, W. (2007). Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart. Neuropsychopharmacology, 32: 239-243. doi:10.1038/sj.npp.1301193.

Brabazon F et al., 2017. Intranasal insulin treatment of an experimental model of moderate traumatic brain injury. J Cereb Blood Flow Metab. 37(9):3203-3218. doi: 10.1177/0271678X16685106.

Brabazon, F. P., Khayrullina, G. I., Frey, W. H., & Byrnes, K. R. (2014, June). INTRANASAL INSULIN TREATMENT OF TRAUMATIC BRAIN INJURY. In JOURNAL OF NEUROTRAUMA (Vol. 31, No. 12, pp. A106-A106). 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA: MARY ANN LIEBERT, INC.

Brain healing. (n.d.). Retrieved from https://en.wikipedia.org/wiki/Brain_healing

Chen, Y., Run, X., Liang, Z., Zhao, Y., Dai, C. L., Iqbal, K., … & Gong, C. X. (2014). Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice. Frontiers in aging neuroscience, 6, 100.

Chua, L. M., Lim, M. L., Chong, P. R., Hu, Z. P., Cheung, N. S., & Wong, B. S. (2012). Impaired neuronal insulin signaling precedes Aβ42 accumulation in female AβPPsw/PS1ΔE9 mice. Journal of alzheimer’s disease, 29(4), 783-791. doi 10.3233/JAD-2012-111880.

Claxton A et al., 2013. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer’s disease. J Alzheimers Dis. 35(4):789-97. doi: 10.3233/JAD-122308.

Craft, S., Baker, L. D., Montine, T. J., Minoshima, S., Watson, G. S., Claxton, A., … & Green, P. S. (2012). Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment. Archives of neurology, 69(1), 29-38. doi:10.1001/archneurol.2011.233.

Dhuria, S., Hanson, L., & Frey, H. (2009). Intranasal Delivery to the Central Nervous System: Mechanisms and Experimental Considerations. Journal of Pharmaceutical Sciences. 99(4): 1654-1673. doi10.1002/jps.21924.

Donahue, D. L., Beck, J., Fritz, B., Davis, P., Sandoval-Cooper, M., Thomas, S. G., . . . Castellino, F. J. (2014). Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. Journal of Neurotrauma, 31(4), 404-410. doi: 10.1089/neu.2013.3089

Fransson, M., Piras, E., Burman, J., Nilsson, B., Essand, M., Lu, B., … & Loskog, A. S. (2012). CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery. J Neuroinflammation, 9(1), 112.

Frey, W. H. (2013). Intranasal insulin to treat and protect against posttraumatic stress disorder. The Journal of nervous and mental disease,201(7), 638-639.

Gladstone Institutes. (2008, December 10). Collagen May Help Protect Brain Against Alzheimer’s Disease. ScienceDaily. Retrieved March 2, 2016 from www.sciencedaily.com/releases/2008/12/081210150713.htm.

Hanson, L. R., & Frey, W. H. (2008). Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease. BMC neuroscience, 9(Suppl 3), S5.

Hayon, Y., Dashevsky, O., Shai, E., Varon, D., & Leker, R. R. (2013). Platelet lysates stimulate angiogenesis, neurogenesis and neuroprotection after stroke. Thrombosis and haemostasis, 110(08), 323-330.

Hayon, Y., Shai, E., Varon, D., & R Leker, R. (2012). The role of platelets and their microparticles in rehabilitation of ischemic brain tissue. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 11(7), 921-925.

Horcajo, C. B., Castillo, M. Z., & Crespo, J. V. (2018). Platelet-rich plasma-derived scaffolds increase the benefit of delayed mesenchymal stromal cell therapy after severe traumatic brain injury. Cytotherapy, 20(3), 314-321.

Jauch-Chara K et al., 2012. Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans. Diabetes. 61(9):2261-8. doi: 10.2337/db12-0025.

Johnson, V. E., Stewart, W., & Smith, D. H. (2010). Traumatic brain injury and amyloid-β pathology: a link to Alzheimer’s disease? Nature Reviews. Neuroscience, 11(5), 361–370. http://doi.org/10.1038/nrn2808.

Leiter, O., Brici, D., Fletcher, S. J., Yong, X. L. H., Widagdo, J., Matigian, N., … & Walker, T. L. (2023). Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice. Nature Communications, 14(1), 4375.

Leiter, O., & Walker, T. L. (2019). Platelets: The missing link between the blood and brain?. Progress in neurobiology, 183, 101695.

Matsui M and Y Tabata. 2012. Enhanced angiogenesis by multiple release of platelet-rich plasma contents and basic fibroblast growth factor from gelatin hydrogels. Acta Biomater. 8(5):1792-801. doi: 10.1016/j.actbio.2012.01.016

Middleton KK et al., 2012. Evaluation of the effects of platelet-rich plasma (PRP) therapy involved in the healing of sports-related soft tissue injuries. Iowa Orthop J. 32:150-63.

Mischley, L. K., Conley, K. E., Shankland, E. G., Kavanagh, T. J., Rosenfeld, M. E., Duda, J. E., … & Padowski, J. M. (2016). Central nervous system uptake of intranasal glutathione in Parkinson’s disease. npj Parkinson’s Disease, 2, 16002.

Middleton, K. K., Barro, V., Muller, B., Terada, S., & Fu, F. H. (2012). Evaluation of the Effects of Platelet-Rich Plasma (PRP) Therapy Involved in the Healing of Sports-Related Soft Tissue Injuries. The Iowa Orthopaedic Journal, 32, 150–163.

Park, C., Hahn, O., Gupta, S., Moreno, A. J., Marino, F., Kedir, B., … & Dubal, D. B. (2023). Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice. Nature Aging, 1-12.

Pitt J et al., 2017. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell. 28(20):2623-2636. doi: 10.1091/mbc.E17-06-0416.

Platelet Rich Plasma (PRP) for brain injuries, retrieved from prpmed.de January 12th, 2023.

Reed, J. R. (2017). Intranasal insulin in treating cortical and hippocampal injury after moderate TBI. Uniformed Services University. Retreived from https://www.usuhs.edu/tsnrp/presentation-abstract/intranasal-insulin-treating-cortical-and-hippocampal-injury-after

Reger, M. A., Watson, G. S., Frey, W. H., Baker, L. D., Chloreton, B., Keeling, M. L. et al. (2006). Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype. Neurobiology of Againg 451-458. doi:10.1016/j.neurobiolaging.2005.03.016

Reed, J. R. (2017). Intranasal insulin in treating cortical and hippocampal injury after moderate TBI. Uniformed Services University.

Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., et al (2008). Intranasal insulin improves cognition and modulates -amyloid in early AD. Departments of Psychiatry and Behavioral Science, Medicine, and Neurology.

Reger, M. A., Watson, G. S., Green, P. S., Baker, L. D., Cholerton, B., Fishel, M. A., … Craft, S. (2008). Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma β-Amyloid in Memory-Impaired Older Adults. Journal of Alzheimer’s Disease : JAD, 13(3), 323–331.

Roggendorf, W., Opitz, H., & Schuppan, D. (1988). Altered expression of collagen type VI in brain vessels of patients with chronic hypertension. Acta Neuropathologica Acta Neuropathol, 77(1), 55-60.

Schiöth, H. B., Craft, S., Brooks, S. J., Frey II, W. H., & Benedict, C. (2012). Brain insulin signaling and Alzheimer’s disease: current evidence and future directions. Molecular neurobiology, 46(1), 4-10. doi 10.1007/s12035-011-8229-6.

Schroer, A. B., Ventura, P. B., Sucharov, J., Misra, R., Chui, M. K., Bieri, G., … & Villeda, S. A. (2023). Platelet factors attenuate inflammation and rescue cognition in ageing. Nature, 1-9.

Shantha, T. R. (2017). Bypassing the BBB: Drug Delivery From the Olfactory Mucosa to the CNS. Drug Development and Delivery, 17(1), 32-37.

Steffens, Y., Le Bon, S. D., Lechien, J., Prunier, L., Rodriguez, A., Saussez, S., & Horoi, M. (2022). Effectiveness and safety of PRP on persistent olfactory dysfunction related to COVID-19. European Archives of Oto-Rhino-Laryngology, 279(12), 5951-5953.

Sun, D. (2014). The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury. Neural regeneration research, 9(7), 688.

Takeuchi, M., Kamei, N., Shinomiya, R., Sunagawa, T., Suzuki, O., Kamoda, H., … & Ochi, M. (2012). Human platelet-rich plasma promotes axon growth in brain–spinal cord coculture. Neuroreport, 23(12), 712-716.

Tang, J. Z., Nie, M. J., Zhao, J. Z., Zhang, G. C., Zhang, Q., & Wang, B. (2020). Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. Journal of Orthopaedic Surgery and Research, 15(1), 1-15.

Tabrizi, A. G., Asadi, M., Mohammadi, M., Yekta, A. A., & Sohrabi, M. (2021). Efficacy of Platelet-Rich Plasma as an Adjuvant Therapy to Endoscopic Sinus Surgery in Anosmia Patients with Sinonasal Polyposis: A Randomized Controlled Clinical Trial. Medical Journal of the Islamic Republic of Iran, 35.

Yan, C. H., Jang, S. S., Lin, H. F. C., Ma, Y., Khanwalker, A. R., Thai, A., & Patel, Z. M. (2022, December). Use of platelet‐rich plasma for COVID‐19 related olfactory loss, a randomized controlled trial. In International Forum of Allergy & Rhinology.

Yan, C. H., Mundy, D. C., & Patel, Z. M. (2020). The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study. Laryngoscope investigative otolaryngology, 5(2), 187-193.

Zhang, Y., Ying, G., Ren, C., Jizhang, Y., Brogan, D., Liu, Z., . . . Ji, X. (2015). Administration of human platelet-rich plasma reduces infarction volume and improves motor function in adult rats with focal ischemic stroke. Brain Research, 1594, 267-273.

Zhang, J., Jiang, R., Liu, L., Watkins, T., Zhang, F., & Dong, J. (2012). Traumatic brain injury-associated coagulopathy. Journal of Neurotrauma, 29(17), 2597-2605. doi: 10.1089/neu.2012.2348

Intranasal Adult Stem Cells

Balyasnikova, I. V., Prasol, M. S., Ferguson, S. D., Han, Y., Ahmed, A. U., Gutova, M., … & Aboody, K. S. (2013). Intranasal delivery of mesenchymal stem cells significantly extends survival of irradiated mice with experimental brain tumors. Molecular Therapy.

Cox, C. S., Hetz, R. A., Liao, G. P., Aertker, B. M., Ewing‐Cobbs, L., Juranek, J., … & Dash, P. K. (2016). Treatment of severe adult traumatic brain injury using bone marrow mononuclear cells. Stem Cells.

Danielyan, L., Schäfer, R., von Ameln-Mayerhofer, A., Buadze, M., Geisler, J., Klopfer, T., … & Buniatian, G. H. (2009). Intranasal delivery of cells to the brain. European journal of cell biology, 88(6), 315-324.

Danielyan, L., Beer-Hammer, S., Stolzing, A., Schäfer, R., Siegel, G., Fabian, C., … & Novakovic, A. (2014). Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer’s and Parkinson’s disease. Cell transplantation,23(Supplement 1), S123-S139.

Danielyan, L., Schäfer, R., von Ameln-Mayerhofer, A., Bernhard, F., Verleysdonk, S., Buadze, M., … & Koehle, C. (2011). Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease. Rejuvenation research, 14(1), 3-16.

Filidou E, Kandilogiannakis L, Tarapatzi G, Spathakis M, Su C, Rai A, Greening DW, Arvanitidis K, Paspaliaris V, Kolios G. A Simplified and Effective Approach for the Isolation of Small Pluripotent Stem Cells Derived from Human Peripheral Blood. Biomedicines. 2023; 11(3):787. https://doi.org/10.3390/biomedicines11030787

Gargiulo, C., Pham, V. H., Nguyen, K. C. D., Trieu, V. L. H., & Duy, T. H. (2016). Autologous Peripheral Blood Stem Cells Increase the Telomere Length in Patient: A Case Report of 13 Patients. J Stem Cell Res Ther, 6(352), 2.

German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ). (2018, December 21). Human blood cells can be directly reprogrammed into neural stem cells. ScienceDaily. Retrieved January 2, 2019 from www.sciencedaily.com/releases/2018/12/181221123721.htm

Henson, N. L., Heaton, M. L., Holland, B. H., Hawkins, K. C., Rawlings, B. A., Eanes, E. A., … & Peebles, B. G. (2005). Karyotypic analysis of adult pluripotent stem calls. Histology and histopathology, 20(3), 769-784.

Liao, G. P., Harting, M. T., Hetz, R. A., Walker, P. A., Shah, S. K., Corkins, C. J., … & Tsao, K. (2015). Autologous bone marrow mononuclear cells reduce therapeutic intensity for severe traumatic brain injury in children. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 16(3), 245.

Liu, Q., & Wang, H. (2014). Tissue regeneration: where nano-structure meets biology (Vol. 2). World Scientific.

Nijboer, C. H., Kooijman, E., Van Velthoven, C. T., Van Tilborg, E., Tiebosch, I. A., Eijkelkamp, N., … & Heijnen, C. J. (2018). Intranasal stem cell treatment as a novel therapy for subarachnoid hemorrhage. Stem cells and development, 27(5), 313-325.

O’Neill, D. W., Jiang, Y., Leary, E., Yavanian, G., Eminli, S., & Marasco, W. A. (2012). A Lin-CD45-CD34+ Population of Extracellular Vesicles in Human Blood That Mimics Very Small Embryonic-Like Stem Cells (VSELs) by Flow Cytometry.

Ratajczak, M. Z., Zuba-Surma, E. K., Wysoczynski, M., Ratajczak, J., & Kucia, M. (2008). Very small embryonic-like stem cells: characterization, developmental origin, and biological significance. Experimental hematology, 36(6), 742-751.

Shantha, T. R. (2017). Bypassing the BBB: Drug Delivery From the Olfactory Mucosa to the CNS. Drug Development and Delivery, 17(1), 32-37.

Sovalat, H., Scrofani, M., Eidenschenk, A., & Hénon, P. (2015). Human very small embryonic-like stem cells are present in normal peripheral blood of young, middle-aged, and aged subjects. Stem cells international, 2016.

Texas A&M University. (2018, December 20). Stem cell-derived neurons stop seizures and improve cognitive function: People with untreatable epilepsy may one day have a treatment. ScienceDaily. Retrieved January 2, 2019 from www.sciencedaily.com/releases/2018/12/181220130219.htm

University of Illinois College of Agricultural, Consumer and Environmental Sciences. (2018, October 17). Stem cell proliferation is controlled directly by nervous system, scientists find. ScienceDaily. Retrieved November 2, 2018 from www.sciencedaily.com/releases/2018/10/181017141033.htm

van Velthoven, C. T., Kavelaars, A., van Bel, F., & Heijnen, C. J. (2010). Nasal administration of stem cells: a promising novel route to treat neonatal ischemic brain damage. Pediatric research, 68, 419-422.

Wei, L. (2018). Stem cell transplantation therapy via intranasal delivery after stroke. Emory University, Atlanta, GA.

Wei, N., Yu, S. P., Gu, X., Taylor, T. M., Song, D., Liu, X. F., & Wei, L. (2013). Delayed intranasal delivery of hypoxic-preconditioned bone marrow mesenchymal stem cells enhanced cell homing and therapeutic benefits after ischemic stroke in mice. Cell transplantation,22(6), 977-991.

William, H. F. I., Danielyan, L., & Gleiter, C. H. (2016). U.S. Patent No. 9,445,991. Washington, DC: U.S. Patent and Trademark Office.

Young, H. E., Hyer, L., Black Jr, A. C., & Robinson Jr, J. S. (2013). Treating Parkinson disease with adult stem cells. J Neurol Disord, 1(2), 1-8.

Young, H. E., & Black, A. C. (2005). Differentiation potential of adult stem cells. In Stem Cells in Endocrinology (pp. 67-92). Humana Press.

Young, H. E., Duplaa, C., Katz, R., Thompson, T., Hawkins, K. C., Boev, A. N., … & Stout, C. (2005). Adult‐derived stem cells and their potential for use in tissue repair and molecular medicine. Journal of cellular and molecular medicine, 9(3), 753-769.

Zhang, J., Jiang, R., Liu, L., Watkins, T., Zhang, F., & Dong, J. (2012). Traumatic brain injury-associated coagulopathy. Journal of Neurotrauma, 29(17), 2597-2605. doi: 10.1089/neu.2012.2348

Zhao, Y., Glesne, D., & Huberman, E. (2003). A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proceedings of the National Academy of Sciences, 100(5), 2426-2431.

Cranial Osteopathy

Barke, L., Gelman, S., & Lipton, J. A. (1997). A successful use of cranial-sacral osteopathy in the treatment of post-traumatic headache following subarachnoid hemorrhage. Am Acad Osteopathy J, 22-23.

Craniosacral Therapy. (2011). Physiotherapy & Occupational Therapy Journal, 4(1), 21-23.

Greenman, P. E., & McPartland, J. M. (1995). Cranial findings and iatrogenesis from craniosacral manipulation in patients with traumatic brain syndrome. The Journal of the American Osteopathic Association, 95(3), 182-8.

Haller, H., Cramer, H., Werner, M., & Dobos, G. (2015). Treating the Sequelae of Postoperative Meningioma and Traumatic Brain Injury: A Case of Implementation of Craniosacral Therapy in Integrative Inpatient Care. Journal Of Alternative & Complementary Medicine, 21(2), 110-112. doi:10.1089/acm.2013.0283

Helmholtz Zentrum München – German Research Center for Environmental Health. (2018, May 18). Flow of cerebrospinal fluid regulates neural stem cell division. ScienceDaily. Retrieved July 2, 2018 from www.sciencedaily.com/releases/2018/05/180518102741.htm

Kozminski, M. (2010). Combat-Related Posttraumatic Headache: Diagnosis, Mechanisms of Injury, and Challenges to TreatmentMADIGAN ARMY MEDICAL CENTER TACOMA WA.

Leder, A., & Yao, S. (2016). Resolution of concussion symptoms after osteopathic manipulative treatment: a case report. The Journal, 116(3), e13.

McCallister, A., Brown, C., Smith, M., Ettlinger, H., & Baltazar, G. A. (2016). Osteopathic manipulative treatment for somatic dysfunction after acute severe traumatic brain injury. Journal of the American Osteopathic Association, 116(12), 810-815.

Moskalenko, Y., Frymann, V., Kravchenko, T., & Weinstein, G. (2003). Physiological Background of the Cranial Rhythmic Impulse and The Primary Respiratory Mechanism.

Patel KG, Sabini RC. Safety of Osteopathic Cranial Manipulative Medicine as an Adjunct to Conventional Postconcussion Symptom Management: A Pilot Study. J Am Osteopath Assoc 2018;. doi: 10.7556/jaoa.2018.061.

Cellular Nutrition

Blaylock, R. L., & Maroon, J. (2011). Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy—a unifying hypothesis. Surgical neurology international, 2.

Benito-Ruiz, et al. (2009). International Journal of Food Sciences and Nutrition.Volume 60, Supplement 2.

Davis, L. M., Pauly, J. R., Readnower, R. D., Rh, J. M., & Sullivan, P. G. (2008). Fasting is neuroprotective following traumatic brain injury. Journal of Neuroscience Research. 86(8), 1812-22. doi: 10.1002/jnr.21628.

European Society of Endocrinology. (2010). Vitamin D deficiency associated with chronic fatigue in brain injured patients. ScienceDaily. Retrieved August 15, 2016 from www.sciencedaily.com/releases/2010/04/100427182609.htm

Fadini, et al. (2007). Glucose tolerance is negatively associated with circulating progenitor cell levels. Diabetologia, 50(10), 2156-2163.

Gasior, M., Rogawski, M. A., & Hartman, A. L. (2006). Neuroprotective and disease-modifying effects of the ketogenic diet. Behavioural pharmacology, 17(5-6), 431.

Geerlings, Hoepelma (1999). Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunology and Medical Microbiology,26, 259-265.

Greco, T., Glenn, T. C., Hovda, D. A., & Prins, M. L. (2016). Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity. Journal of Cerebral Blood Flow & Metabolism, 36(9), 1603-1613.

Hankenson, et al. (2000). Omega-3 Fatty Acids Enhance Ligament Fibroblast Collagen Formation in Association with Changes in Interleukin-6 Production. Proceedings of the Society for Experimental Biology and Medicine, 223(1), 88-95.

Huskisson, E., Maggini, S., & Ruf, M. (2007). The role of vitamins and minerals in energy metabolism and well-being. Journal of international medical research, 35(3), 277-289.

McNally, M. A., & Hartman, A. L. (2012). Ketone bodies in epilepsy. Journal of neurochemistry, 121(1), 28-35.

Oreffo, et al. (n.d.) Maternal protein deficiency affects mesenchymal stem cell activity in the developing offspring. Bone, 33(1), 100-107.

Peterkofsky, B. (1991). Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy. Am J Clin Nutr, 54(6), 1135S-1140S.

Pillsbury, L., Oria, M., & Erdman, J. (Eds.). (2011). Nutrition and traumatic brain injury: improving acute and subacute health outcomes in military personnel. National Academies Press.

Rho, J. M., & Stafstrom, C. E. (2012). The ketogenic diet as a treatment paradigm for diverse neurological disorders. Frontiers in pharmacology, 3, 59.

Rhyu, H. S., Cho, S. Y., & Roh, H. T. (2014). The effects of ketogenic diet on oxidative stress and antioxidative capacity markers of Taekwondo athletes. Journal of exercise rehabilitation, 10(6), 362.

SHANTHA, T. R. (2020). LITHIUM, ALZHEIMER’S, and Other Dementias. Life Extension, 26(12), 34–38.

Stafstrom, C. E., & Rho, J. M. (2012). The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders. Frontiers in Pharmacology, 3, 59. http://doi.org/10.3389/fphar.2012.00059.

Sullivan, P. G., Rippy, N. A., Dorenbos, K., Concepcion, R. C., Agarwal, A. K., & Rho, J. M. (2004). The ketogenic diet increases mitochondrial uncoupling protein levels and activity. Annals of neurology, 55(4), 576-580.

Toklu, H. Z., & Tümer, N. (2015). Oxidative stress, brain edema, blood–brain barrier permeability, and autonomic dysfunction from traumatic brain injury.

UHN Staff. (2015). Vitamins for Memory Loss and Stroke Prevention – These 3 Are Critical. University Health News Daily. Retrieved August 15, 2016 from http://universityhealthnews.com/daily/memory/vitamins-for-memory-loss-and-stroke-prevention-these-3-are-critical/

Yu, J., Sun, M., Chen, Z., Lu, J., Liu, Y., Zhou, L., … & Chui, D. (2010). Magnesium modulates amyloid-β protein precursor trafficking and processing. Journal of Alzheimer’s Disease, 20(4), 1091-1106.

https://scholar.google.com/scholar?q=rapamycin+and+brain+injury&hl=en&as_sdt=0&as_vis=1&oi=scholart

Abe, K., Shimada, R., Okada, Y., & Kibayashi, K. (2016). Traumatic brain injury decreases serotonin transporter expression in the rat cerebrum. Neurological research, 38(4), 358-363.

Almis, B. H., & Aksoy, I. (2018). Mean platelet volume level in patients with generalized anxiety disorder. Psychiatry and Clinical Psychopharmacology, 28(1), 43-47.

Army Announces FDA Clearance of Whole Blood Rapid Test to Help with Assessment of Traumatic Brain Injury

Ayers, ME. 1987. Electroencephalic neurofeedback and closed head injury of 250 individuals. Head Injury Frontier. National Head Injury Foundation, 380.

Balan, I. S., Saladino, A. J., Aarabi, B., Castellani, R. J., Wade, C., Stein, D. M., … Fiskum, G. (2013). Cellular alterations in human traumatic brain injury: changes in mitochondrial morphology reflect regional levels of injury severity. Journal of neurotrauma, 30(5), 367–381. doi:10.1089/neu.2012.2339

Birn RM 2013, The effect of scan length on the reliability of resting-state fMRI connectivity estimates. Neuroimage. 550-8. doi: 10.1016/j.neuroimage.2013.05.099.

Blaylock, R. L., & Maroon, J. (2011). Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy—a unifying hypothesis. Surgical neurology international, 2.

DeGraba, T. J., Williams, K., Koffman, R., Bell, J. L., Pettit, W., Kelly, J. P., … & Pickett, T. C. (2021). Efficacy of an interdisciplinary intensive outpatient program in treating combat-related traumatic brain injury and psychological health conditions. Frontiers in neurology, 11, 1741.

DeKosky ST et al., 2007. Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans. Arch Neurol. 64(4):541-4.

Dardia, G. P., & Remington Nevin, M. D. (2019). Neurotoxicity associated with traumatic brain injury, blast, chemical, heavy metal and quinoline drug exposure. Alternative therapies in health and medicine, 25(1), 28-34.

Edwards, G et al. 2017. Amyloid-beta and tau pathology following repetitive mild traumatic brain injury. Biochem Biophys Res Commun. 2017 Feb 19;483(4):1137-1142.

Gladstone Institutes. (2008). Collagen May Help Protect Brain Against Alzheimer’s Disease. ScienceDaily. Retrieved August 15, 2016 from http://www.sciencedaily.com/releases/2008/12/081210150713.htm

Grant DA et al., 2017. Repeat mild traumatic brain injury in adolescent rats increases subsequent β-amyloid pathogenesis. J Neurotrauma. doi: 10.1089/neu.2017.5042.

Gray, 2017. An Overview of the Use of Neurofeedback Biofeedback for the Treatment of Symptoms of Traumatic Brain Injury in Military and Civilian Populations. Med Acupunct. 29(4):215-219. doi: 10.1089/acu.2017.1220.

Gualtieri, C. T., & Johnson, L. G. (2006). Reliability and validity of a computerized neurocognitive test battery, CNS Vital Signs. Archives of Clinical Neuropsychology, 21(7), 623-643.

Gunther, N. & Queen, E. 2013. What Physical and Cognitive Rest Really Mean After a Concussion. Brainline. Retrieved from http://www.brainline.org/content/multimedia.php?id=9022

Hamblin M. R. (2016). Shining light on the head: Photobiomodulation for brain disorders. BBA clinical, 6, 113–124. https://doi.org/10.1016/j.bbacli.2016.09.002

Harris, B., Andrews, P. J., Murray, G. D., Forbes, J., & Moseley, O. (2012). Systematic review of head cooling in adults after traumatic brain injury and stroke. Health technology assessment (Winchester, England), 16(45), 1.

Hipskind, G. Light therapy improves cognitive function after traumatic brain injury. Research Outreach, 108, 54-57.

Hipskind, S. G., Grover Jr, F. L., Fort, T. R., Helffenstein, D., Burke, T. J., Quint, S. A., … & Hurtado, T. (2018). Pulsed transcranial red/near-infrared light therapy using light-emitting diodes improves cerebral blood flow and cognitive function in veterans with chronic traumatic brain injury: a case series. Photomedicine and laser surgery.

Hipskind, G. (2019). Evaulating and Treating Traumatic Brain Injury. OpenAccessGovernment.org.

Johnston, SJ et al. 2010. Neurofeedback: A promising tool for the self-regulation of emotion networks. Neuroimage, 49(1), 1066-1072.

Johnson VE et al. 2012. Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans. Brain Pathol. 2012 Mar; 22(2): 142–149.

Johnson, P. K., Fino, P. C., Wilde, E. A., Hovenden, E. S., Russell, H. A., Velez, C., … & Tate, D. F. (2024). The Effect of Intranasal Plus Transcranial Photobiomodulation on Neuromuscular Control in Individuals with Repetitive Head Acceleration Events. Photobiomodulation, Photomedicine, and Laser Surgery.

Karelina, K., & Weil, Z. M. (2016). Neuroenergetics of traumatic brain injury. Concussion, 1(2).

Keller, I. 2001. Neurofeedback Therapy of Attention Deficits in Patients with Traumatic Brain. Journal of Neurotherapy 5:19-32.

Koyama, T., Kuriyama, N., Ozaki, E., Matsui, D., Watanabe, I., Miyatani, F., … & Yoshida, T. (2016). Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study. BMC neurology, 16(1), 253.

Lombardo MV et al., 2016. Improving effect size estimation and statistical power with multi-echo fMRI and its impact on understanding the neural systems supporting mentalizing. Neuroimage. 142:55-66. doi: 10.1016/j.neuroimage.2016.07.022.

Lucke-Wold, B. P., Turner, R. C., Logsdon, A. F., Bailes, J. E., Huber, J. D., & Rosen, C. L. (2014). Linking traumatic brain injury to chronic traumatic encephalopathy: identification of potential mechanisms leading to neurofibrillary tangle development. Journal of neurotrauma, 31(13), 1129-1138.

May G. et al., 2013. Neurofeedback and traumatic brain injury: a literature review. Ann Clin Psychiatry. 25(4):289-96

Morley, W. A. (2018). Environmental Subconcussive Injury, Axonal Injury, and Chronic Traumatic Encephalopathy. Frontiers in neurology, 9, 166.

Munivenkatappa A et al., 2014. EEG Neurofeedback therapy: Can it attenuate brain changes in TBI? NeuroRehabilitation. 35(3):481-4.

Murphy K, Garavan H. 2004. An empirical investigation into the number of subjects required for an event-related fMRI study. Neuroimage. 22(2):879-85.

Mumford JA, Nichols TE. 2008. Power calculation for group fMRI studies accounting for arbitrary design and temporal autocorrelation. Neuroimage. 39(1):261-8.

Nelson, DV and ML Etsy. 2012. Neurotherapy of traumatic brain injury/posttraumatic stress symptoms in OEF/OIF veterans. J Neuropsychiatry Clin Neurosci. 2012 Spring;24(2):237-40. doi: 10.1176/appi.neuropsych.11020041.

Papa, L., Zonfrillo, M. R., Welch, R. D., Lewis, L. M., Braga, C. F., Tan, C. N., … & Giordano, P. A. (2019). Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive, subconcussive and non-concussive trauma: a prospective cohort study. BMJ paediatrics open, 3(1).

Rostami et al., 2014. Silent Epidemic: The Effects of Neurofeedback on Quality-of-Life. Indian J Psychol Med. 36(1):40-4.

Rostami R et al., 2017. Effects of neurofeedback on the short-term memory and continuous attention of patients with moderate traumatic brain injury: A preliminary randomized controlled clinical trial. Chin J Traumatol. pii: S1008-1275(16)30160-2.

Russo, M. V., & McGavern, D. B. (2017). Distinct Myeloid Cell Subsets Promote Angiogenesis and Damaged Tissue Clearance Following Mild Traumatic Brain Injury.

Scott G 2016. Amyloid pathology and axonal injury after brain trauma.

Neurology. 86(9):821-8. doi: 10.1212/WNL.0000000000002413.

Shantha, T. R. (2017). Bypassing the BBB: Drug Delivery From the Olfactory Mucosa to the CNS. Drug Development and Delivery, 17(1), 32-37.

SHANTHA, T. R. (2020). LITHIUM, ALZHEIMER’S, and Other Dementias. Life Extension, 26(12), 34–38.

Simkin DR et al., 2014. Quantitative EEG and neurofeedback in children and adolescents: anxiety disorders, depressive disorders, comorbid addiction and attention-deficit/hyperactivity disorder, and brain injury. Child Adolesc Psychiatr Clin N Am. 23(3):427-64. doi: 10.1016/j.chc.2014.03.001.

Sun D et al., 2014. The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury. Neural Regen Res. 2014 Apr 1;9(7):688-92. doi: 10.4103/1673-5374.131567.

Surmeli T et al. 2017. Quantitative EEG Neurometric Analysis-Guided Neurofeedback

Treatment in Postconcussion Syndrome (PCS): Forty Cases. How Is Neurometric Analysis Important for the Treatment of PCS and as a Biomarker? Clin EEG Neurosci.48(3):217-230. doi: 10.1177/1550059416654849.

Traumatic Brain Injury Recovery with Photobiomodulation: Cellular Mechanisms, Clinical Evidence, and Future Potential

Tinius, TP and KA Tinius. 2000. Changes After EEG Biofeedback and Cognitive Retraining in Adults with Mild Traumatic Brain Injury and Attention Deficit Hyperactivity Disorder. Journal of Neurotherapy 42:27-44.

Yousefzadeh-Chabok, S. 2015. The role of early posttraumatic neuropsychological outcomes in the appearance of latter psychiatric disorders in adults with brain trauma. Asian J Neurosurg. 10(3):173-80.

UHN Staff. 2015. Vitamins for Memory Loss and Stroke Prevention – These 3 Are Critical. University Health News Daily. Retrieved August 15, 2016 from http://universityhealthnews.com/daily/memory/vitamins-for-memory-loss-and-stroke-prevention-these-3-are-critical/

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