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Case Report for TBI (Traumatic Brain Injury) Patient Treated with A Protocol of HBOT (Hyperbaric Oxygen Therapy), Autologous Human Plasma, Cranial Therapy, EEG Biofeedback, IV Nutrition, and Adult Stem Cells

Dr. John C Hughes, DO

Keywords: traumatic brain injury, platelet rich plasma, cranial osteopathy, adult stem cells, adipose derived stem cells, bone marrow aspirate, closed head injury, neuropsychiatric disease, post-concussion syndrome, blastomere-like stem cells, totipotent, intravenous nutrition


Traumatic brain injury (TBI) is one of the most prevalent injuries in the U.S. leading to death and long-term disability. CDC estimates are that 1.7 million individuals suffer annually with severe to moderate TBI due to blunt trauma or motor vehicle accidents as the biggest causes. Modern medicine proves very efficacious in the golden hour after the injury to save many patients from death. However, memory loss, inability to concentrate, loss of motor function, decision-making, emotional affect, pain, and other brain damage symptoms often confine these patients to a prison within their own bodies or compel them to suicide.
Most treatments for chronically debilitated traumatic brain injury patients have involved pharmaceutical drugs, occupational and physical rehabilitation, speech therapy, and cognitive maintenance. Many patients resign to accept their condition and gain very little improvement in their condition or begin a slow decline of cognitive or motor function. However, some patients gain some improvements using hyperbaric oxygen therapies (HBOT) at specific protocols (as developed by Dr. Paul Harsch—see
While HBOT by itself as a treatment for TBI has gained moderate acceptance by the medical community around the U.S., it has been found that an entire protocol utilizing multiple modalities over a 3-9 month period is potentially the most effective way to treat sub-acute and chronic traumatic brain injuries. This protocol is not limited to, but may include, HBOT, autologous human plasma, adult stem cells, and cranial therapy along with the adjunctive therapies of EEG biofeedback, IV nutrition, TMS (transcranial magnetic stimulation), and low-level light therapy. Although several modalities in the protocol have been utilized singularly, the combination of these therapies in a synergistic manner is the novel step towards the long-term remediation of traumatic brain injury. Also, particularly unique to this patent application is the administration of activated plasma (in a proprietary solution of nutrients and drugs) as well as plasma-derived stem cells directly as a drip into the frontal area of the brain.
The following case study describes a male patient with a traumatic brain injury due to a serious motor vehicle accident in August 2012 where he experienced a direct blow to the frontal area of the head and brain. This patient experienced significant post-concussion symptoms secondary to the TBI including insomnia, photosensitivity, hyperacusis, memory loss, decreased ability to concentrate, emotional distress, depression, loss of libido, daily headache pain, loss of executive function as well as other related symptoms.
This patient, who will be referred to as Mr. Chad, after initial evaluation and treatment with neurology and a neuropsychologist continued to experience significant symptoms 11 months after the motor vehicle accident in August 2012. In the late spring of 2013, Mr. Chad had experienced some relief of symptoms with the daily use of a home hyperbaric oxygen chamber and five sessions of EEG biofeedback in Boulder, Colorado. However, Mr. Chad was still significantly mentally impaired in mid-July 2013 when he presented to Dr. John Hughes in Basalt, Colorado (see Appendix A for Mr. Chad’s personal historical review of his experience). Mr. Chad received an evaluation by Dr. John Hughes, D.O. in July 2013 for commercialized HBOT therapy for traumatic brain injury. After an initial 25 sessions of HBOT at 1.5 atmospheres, Dr. Hughes offered cranial therapy and activated plasma to Mr. Chad in the form of injections, intravenous administration, and a intranasal drip. Mr. Chad also was given IV nutrition to assist with his healing and recovery. He continued to receive 25 more HBOT treatments until the end of September 2013. In October 2013, Mr. Chad also received adult stem cells derived from fat, plasma, and bone marrow in Miami, Florida.
From July 2013 to October 2013, Mr. Chad made significant, rapid improvements in cognition, executive function, emotional affect, insomnia, fatigue, fear, and pain along with having a decrease in light and sound sensitivity. In July 2013, Mr. Chad reported living in darkness being only able to “withstand five seconds of sunlight.” In October 2013, Mr. Chad was able to fly on an airplane to Miami, Florida after only three months of treatment with HBOT, activated plasma, IV nutrition, and cranial osteopathic therapy. Six months after receiving adult stem cells, Mr. Chad demonstrated continued improvement and stabilization of his mental state in April 2014. His neuropsychiatric evaluation by Dr. Hughes’ clinic showed improvements (see Appendix B for Mr. Chad’s pretreatment neurophychiatric testing and Appendix C for post-treatment neuropsychiatric testing). Third party follow-up post-treatment evaluations by neuropsychologist Dr. Mary Ann Keatley, PhD of Boulder, Colorado also demonstrated improvements.
Note: Because Mr. Chad’s traumatic brain injury was more neuro-psychological than purely neurological, MRI and CT scans were not relied upon to determine significant effects of the protocol offered by Dr. Hughes.1 It is noted that Mr. Chad had “fraying of his spinal cord” in the thoracic area as well as a cervical disc extrusion upon initial MRI but no major defects on MRI of the brain were observed upon initial presentation to Dr. Hughes in July 2013. The MRI of Mr. Chad’s cervical spine is listed in the case presentation below. Also see Appendix D for Mr. Chad’s cervical and lumbar spine studies.

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