View YouTube Video
1. TBI THERAPY WEBINAR: HYPERBARIC OXYGEN THERAPY FOR TBI By Dr. John Hughes January 31st, 2018
2. DR. JOHN HUGHES, DO • Doctor of Osteopathy • From Georgia • Arizona College of Osteopathic Medicine in 2007 • Aspen Integrative Medicine in 2009 • TBI Therapy in 2014
3. LEARNING OBJECTIVE WHAT IS A TRAUMATIC BRAIN INJURY? What is hyperbaric oxygen therapy? How does hyperbaric oxygen therapy help TBI?
4. WHAT CAUSES A BRAIN INJURY? • TRAUMATIC – blunt force OR blast trauma • Anoxic – loss of oxygen • Chemical
5. DO YOU HAVE THESE SYMPTOMS? Cognitive • Memory decline and loss • Slow reaction time • Inability to pay attention • Executive dysfunction • Slow learning • Interrupted speech • Difficulty understanding • Unable to concentrate • Confusion • Difficulty communicating thoughts • Unable to plan, reason, problem-solve Physical • Headache • Fatigue • Sleep disorders • Vertigo or dizziness • Tinnitus or hyperacusis • Photosensitivity • Anomia • Reduced tolerance to psychotropic medications • Disorientation • Loss of mobility • Seizures • Loss of smell Psychological • Irritability • Easy frustration • Tension • Anxiety • Affective lability • Personality changes • Disinhibition • Apathy • Suspiciousness • Suicidality • Depression • PTSD
6. CONCUSSION (BRAIN INJURY) = METABOLIC CRISIS “The brain is in a metabolic crisis in a concussion, potassium ion from inside the cell going extracellular, calcium ions going intracellular, neurotransmitters widely released in a chaotic manner. It takes energy to pump that potassium back, put the neurotransmitters back on so the cell can function.” Dr. Robert Cantu MD
7. CONCUSSION (BRAIN INJURY) = METABOLIC CRISIS “The brain is in a metabolic crisis in a concussion, potassium ion from inside the cell going extracellular, calcium ions going intracellular, neurotransmitters widely released in a chaotic manner. It takes energy to pump that potassium back, put the neurotransmitters back on so the cell can function.” Dr. Robert Cantu MD
8. What Gives a Corvette’s Engine the Most Power? A. Gasoline B. Oil C. Supercharger
9. What Gives a Human Brain the Most Power? A. Sugar B. Fat C. Pressurized Oxygen
10. WHAT DOES A BRAIN INJURY NEED TO HEAL? PRESSURIZED OXYGEN
11. WHAT IS HYPERBARIC OXYGEN THERAPY (HBOT)?
12. THE MEDICAL GRADE CHAMBER • Pressurized chamber • 100% oxygen in chamber or by mask • Approved by the American Medical Association, FDA, and Medicare • Primarily used for wound care, radiation injuries, and skin healing, and diving accidents
13. Body absorbs 10- 15x its normal supply of oxygen Oxygen dissolves into ALL of the bodies fluids Oxygen flows to areas in need of circulation Enhances white blood cells and new blood vessels HBOT AND THE BODY
14. HBOT AND THE BRAIN Induces neuroplasticity Increases tissue oxygenation Restores blood supplyGenerates new capillary networks Increases stem cells in the blood
15. 2 hours = 3x amount of stem cells circulating stem cells in your blood 20 sessions = 800% more stem cells circulating stem cells in your blood HBOT AND ADULT STEM CELLS
16. • Stem cells migrate to damaged tissues and help them regenerate • Stem cells from the blood are essential to healing nerve and brain tissue HBOT AND ADULT STEM CELLS
17. TBI THERAPY HBOT PROTOCOL Medical Grade HBOT 10 – 20 before stem cell infusion 10 – 20 after stem cell infusion Home HBOT Chamber 5 – 7 days/wk 1 month before stem cell infusion 5 – 7 days/wk 2 – 9 months after stem cell infusion
18. CLINICAL RESULTS • Improved cognitive status • Improved memory performance • Improved quality of life
19. • Improved energy • Improved sleep • Less headache pain • Improved mood PATIENTS REPORT
20. Q&A Learn more at tbitherapy.com email@example.com | 303-447-1257
21. Boussi-Gross, R., Golan, H., Fishlev, G., Bechor, Y., Volkov, O., et al. (2013) Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury – Randomized Prospective Trial. PLoS ONE 8(11): e79995. doi: 10.1371/journal.pone.0079995. Brabazon, F. P., Khayrullina, G. I., Frey, W. H., & Byrnes, K. R. (2014, June). INTRANASAL INSULIN TREATMENT OF TRAUMATIC BRAIN INJURY. In JOURNAL OF NEUROTRAUMA (Vol. 31, No. 12, pp. A106-A106). 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA: MARY ANN LIEBERT, INC. Danielyan, L., Beer-Hammer, S., Stolzing, A., Schäfer, R., Siegel, G., Fabian, C., … & Novakovic, A. (2014). Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer’s and Parkinson’s disease. Cell transplantation,23(1), S123-S139. European Society of Endocrinology. (2010). Vitamin D deficiency associated with chronic fatigue in brain injured patients. ScienceDaily. Retrieved August 15, 2016 from www.sciencedaily.com/releases/2010/04/100427182609.htm Gladstone Institutes. (2008). Collagen May Help Protect Brain Against Alzheimer’s Disease. ScienceDaily. Retrieved August 15, 2016 from www.sciencedaily.com/releases/2008/12/081210150713.htm Gunther, N. & Queen, E. (2013). What Physical and Cognitive Rest Really Mean After a Concussion. Brainline. Retrieved from http://www.brainline.org/content/multimedia.php?id=9022 Haller, H., Cramer, H., Werner, M., & Dobos, G. (2015). Treating the sequelae of postoperative meningioma and traumatic brain injury: a case of implementation of craniosacral therapy in integrative inpatient care. The Journal of Alternative and Complementary Medicine, 21(2), 110-112. Huskisson, E., Maggini, S., & Ruf, M. (2007). The role of vitamins and minerals in energy metabolism and well-being. Journal of international medical research, 35(3), 277-289. Kurtz, S. (2008). U.S. Patent Application No. 12/077,296. Retrieved August 15, 2016 from https://www.google.com/patents/US20090012039 McNally, M. A., & Hartman, A. L. (2012). Ketone bodies in epilepsy. Journal of neurochemistry, 121(1), 28-35. Mischley, L. K., Conley, K. E., Shankland, E. G., Kavanagh, T. J., Rosenfeld, M. E., Duda, J. E., … & Padowski, J. M. (2016). Central nervous system uptake of intranasal glutathione in Parkinson’s disease. npj Parkinson’s Disease, 2, 16002. Moskalenko, Y., Frymann, V., Kravchenko, T., & Weinstein, G. (2003). Physiological background of the Cranial Rhythmic Impulse and the Primary respiratory Mechanism. Am Acad Osteopath J, 13(2), 21- 33. Rho, J. M., & Stafstrom, C. E. (2012). The ketogenic diet as a treatment paradigm for diverse neurological disorders. Frontiers in pharmacology, 3, 59. Sun, D. (2014). The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury. Neural regeneration research, 9(7), 688.). Thom, S. R., Bhopale, V. M., Velazquez, O. C., Goldstein, L. J., Thom, L. H., & Buerk, D. G. (2006). Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology-Heart and Circulatory Physiology, 290(4), H1378-H1386. Tithon Biotech (n.d.). Retrieved from http://tithonbiotech.com/index/ UHN Staff. (2015). Vitamins for Memory Loss and Stroke Prevention – These 3 Are Critical. University Health News Daily. Retrieved August 15, 2016 from http://universityhealthnews.com/daily/memory/vitamins-for-memory-loss-and-stroke-prevention-these-3-are-critical/ Van Velthoven, C. T., Kavelaars, A., van Bel, F., & Heijnen, C. J. (2010). Nasal administration of stem cells: a promising novel route to treat neonatal ischemic brain damage. Pediatric research, 68, 419- 422.