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1. TBI THERAPY WEBINAR: HYPERBARIC OXYGEN THERAPY FOR TBI By Dr. John Hughes January 31st, 2018

2. DR. JOHN HUGHES, DO • Doctor of Osteopathy • From Georgia • Arizona College of Osteopathic Medicine in 2007 • Aspen Integrative Medicine in 2009 • TBI Therapy in 2014

3. LEARNING OBJECTIVE WHAT IS A TRAUMATIC BRAIN INJURY? What is hyperbaric oxygen therapy? How does hyperbaric oxygen therapy help TBI?

4. WHAT CAUSES A BRAIN INJURY? • TRAUMATIC – blunt force OR blast trauma • Anoxic – loss of oxygen • Chemical

5. DO YOU HAVE THESE SYMPTOMS? Cognitive • Memory decline and loss • Slow reaction time • Inability to pay attention • Executive dysfunction • Slow learning • Interrupted speech • Difficulty understanding • Unable to concentrate • Confusion • Difficulty communicating thoughts • Unable to plan, reason, problem-solve Physical • Headache • Fatigue • Sleep disorders • Vertigo or dizziness • Tinnitus or hyperacusis • Photosensitivity • Anomia • Reduced tolerance to psychotropic medications • Disorientation • Loss of mobility • Seizures • Loss of smell Psychological • Irritability • Easy frustration • Tension • Anxiety • Affective lability • Personality changes • Disinhibition • Apathy • Suspiciousness • Suicidality • Depression • PTSD

6. CONCUSSION (BRAIN INJURY) = METABOLIC CRISIS “The brain is in a metabolic crisis in a concussion, potassium ion from inside the cell going extracellular, calcium ions going intracellular, neurotransmitters widely released in a chaotic manner. It takes energy to pump that potassium back, put the neurotransmitters back on so the cell can function.” Dr. Robert Cantu MD

7. CONCUSSION (BRAIN INJURY) = METABOLIC CRISIS “The brain is in a metabolic crisis in a concussion, potassium ion from inside the cell going extracellular, calcium ions going intracellular, neurotransmitters widely released in a chaotic manner. It takes energy to pump that potassium back, put the neurotransmitters back on so the cell can function.” Dr. Robert Cantu MD

8. What Gives a Corvette’s Engine the Most Power? A. Gasoline B. Oil C. Supercharger

9. What Gives a Human Brain the Most Power? A. Sugar B. Fat C. Pressurized Oxygen

10. WHAT DOES A BRAIN INJURY NEED TO HEAL? PRESSURIZED OXYGEN

11. WHAT IS HYPERBARIC OXYGEN THERAPY (HBOT)?

12. THE MEDICAL GRADE CHAMBER • Pressurized chamber • 100% oxygen in chamber or by mask • Approved by the American Medical Association, FDA, and Medicare • Primarily used for wound care, radiation injuries, and skin healing, and diving accidents

13. Body absorbs 10- 15x its normal supply of oxygen Oxygen dissolves into ALL of the bodies fluids Oxygen flows to areas in need of circulation Enhances white blood cells and new blood vessels HBOT AND THE BODY

14. HBOT AND THE BRAIN Induces neuroplasticity Increases tissue oxygenation Restores blood supplyGenerates new capillary networks Increases stem cells in the blood

15. 2 hours = 3x amount of stem cells circulating stem cells in your blood 20 sessions = 800% more stem cells circulating stem cells in your blood HBOT AND ADULT STEM CELLS

16. • Stem cells migrate to damaged tissues and help them regenerate • Stem cells from the blood are essential to healing nerve and brain tissue HBOT AND ADULT STEM CELLS

17. TBI THERAPY HBOT PROTOCOL Medical Grade HBOT 10 – 20 before stem cell infusion 10 – 20 after stem cell infusion Home HBOT Chamber 5 – 7 days/wk 1 month before stem cell infusion 5 – 7 days/wk 2 – 9 months after stem cell infusion

18. CLINICAL RESULTS • Improved cognitive status • Improved memory performance • Improved quality of life

19. • Improved energy • Improved sleep • Less headache pain • Improved mood PATIENTS REPORT

20. Q&A Learn more at tbitherapy.com info@tbitherapy.com | 303-447-1257

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