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2. WHO I AM • Dr. John Hughes, DO • Practice osteopathic, integrative, and regenerative medicine • Graduated from Arizona College of Osteopathic Medicine in 2007 • Opened Aspen Integrative Medicine in 2009 • Opened TBI Therapy in 2014

3. LEARNING OBJECTIVE Learn about the individual mechanisms and benefits of each regenerative modality offered at TBI Therapy to treat TBI.

4. MAINSTREAM TREATMENTS • Occupational and physical rehabilitation • Speech therapy • Pharmaceutical drugs • Cognitive maintenance exercises • Do not regenerate the damaged brain • Do not combine regenerative treatments • Can be prohibitive for patients and their families, both in cost and time = Simply cope with the condition

5. TBI THERAPY PROTOCOL Hyperbaric Oxygen Therapy Intranasal Therapies IV Nutrition Cranial Osteopathy Ketogenic Diet and MCT Oil

6. HYPERBARIC OXYGEN THERAPY (HBOT) • Allows the body to absorb about 10-15 times its normal supply of oxygen • Stimulates the growth of tissue, bone and blood vessels, reduce inflammation, and mobilizes stem cells • 2 hours of HBOT triples the patients own circulating stem cells • 20 sessions of HBOT increases circulating stem cells to 8 fold (800%)

7. INTRANASAL PRP/INSULIN • Improves brain ATP production • Decreases CSF cortisol • Improves neuronal viability in the hippocampus • Increases the expression of anti- inflammatory microglia • Reduces beta-amyloid and tau protein deposition • Autologous plasma contains growth factors and cytokines to aid the injured brain

8. INTRANASAL STEM CELLS • Peripheral blood derived pluripotent stem cells • Plasma contains hundreds of thousands of these cells per mL • Have regenerative and reparative properties • Have been used to treat ischemic brain damage by reducing gray and white matter loss • Downregulate neuroinflammatory cytokines

9. IV NUTRITION • Includes PRP, stem cells, NAD+, Myer’s cocktail with potassium, magnesium, calcium, B-complex, B5, B6, and B12, ascorbate followed by a glutathione push • Vitamin D deficiency has been found in over 65% of TBI patients • B vitamin supplementation improves memory, mood, and energy levels

10. CRANIAL OSTEOPATHY • Manual manipulation of the cranial bones and membranes to allow the cerebral spinal fluid to flow properly • The central nervous system, including the brain and spinal cord, has a subtle, rhythmic pulsation • This rhythmic pulsation can be blocked in brain injuries – impedes CSF and blood flow • Effective at treating vertigo and headaches associated with TBIs

11. KETOGENIC DIET • Proven treatment for patients suffering from epileptic seizures • Produce cortical sparing and less apoptotic neuro-degeneration • Overall improvements in cognitive and motor functioning • Increase the available calming neurotransmitter GABA • With less glutamate, there is less oxidative stress and improved neuroprotection • MCT oils are a rich source of ketone bodies

12. 2 DAY PROTOCOL 60 Minute Physician Consultation Cranial Osteopathy Ketogenic Diet Hyperbaric Oxygen Therapy (2 sessions) Intranasal PRP (Platelet Rich Plasma) Intravenous PRP (Platelet Rich Plasma) + Nutrition Intranasal PRP-PDSC (Plasma and Platelet Derived Stem Cells) Intravenous PRP-PDSC (Plasma and Platelet Derived Stem Cells) + NAD Take home supplements: Brain Octane MCT Oil by Bulletproof, Elk Antler by High Wire Ranch, BrainOn by E3 Live, Stem XCell, and Fat for Fuel by Dr. Mercola Take home drugs and devices: insulin for personal administration and brainwave training player

13. CLINICAL RESULTS • More mental clarity • Improved memory • Improved executive function/decision making • More stable emotions and less stress • Better ability to cope with pain • More physical and mental energy

14. CASE REPORT 46 YEAR-OLD MALE FROM BOULDER, CO • Presented with: • Light and sound sensitivity • Could not drive • Emotionally unstable • Headaches daily • Inability to carry on conversation • Inability to do math or read • Loss of libido • Depression and anxiety • Insomnia • Memory loss • After Treatment: • “Memory download” • “An awakening” • Mood and personality improvements • Improvements intellectually, physiologically, and psychologically • Improved ability to read • Able to turn on lights and get on computer / TV • Able to drive • Sleep normalized

15. CASE REPORT 46 YEAR-OLD MALE FROM BOULDER, CO “Dr. Hughes then administered the plasma into the right nostril. After this it was like a stream of information had been let loose like a dam that had busted. I saw clips of memories such as faces, numbers, and letters. After 5 minutes the stream of thoughts slowed down. I needed sugar during the process due to slight hypoglycemia. Upon completing the second treatment for the day I had the same reaction and results except the stream of information slowed down and I could recognize images and conversations I had with people. It was almost like a computer file had been opened full of letters, numbers, and words. I started having expanded thought. I felt for the first time in a year that I had some clarity. The initial feeling of bubbly effervescent seemed to give me life. The light was on in the back of a dark warehouse. I was excited to read more than 2-3 sentences without triggering a migraine. I found that I was able to get back on the computer and learn more about my trauma and recent treatment. Within the following days it was like an awakening. I could turn on lights for a few minutes and keep the TV on. It seemed like a light switch was turned back on inside my head even though it was dim. There was new activity occurring.”

16. Q&A Learn more at or call 303-447-1257

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